Road to perdition: Zeb1-dependent and –independent ways to metastasis

Plant Biology: Gatekeepers of the Road to Protein Perdition

Targeting membrane proteins for degradation requires the sequential action of ESCRT sub-complexes ESCRT-0 to ESCRT-III. Although this machinery is generally conserved among kingdoms, plants lack the essential ESCRT-0 components. A new report closes this gap by identifying a novel protein family that substitutes for ESCRT-0 function in plants.

ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism.

Epithelial tumor cells that have undergone epithelial-to-mesenchymal transition (EMT) are typically prone to metastasis and drug resistance and contribute to a poor clinical outcome. The transcription factor ZEB1 is a known driver of EMT, and mediators of ZEB1 represent potential therapeutic targets for metastasis suppression. Here, we have shown that phosphatidylinositol 3-kinase-targeted (PI3...

A hard road: finding ways to reduce teen tobacco use.

iranian english learners’ perception and personality: a dual approach to investigating influential factors on willingness to communicate

abstract previous studies on willingness to communicate (wtc) have shown the influence of many individual or situational factors on students’ tendency to engage in classroom communication, in which wtc has been viewed either at the trait-level or situational level. however, due to the complexity of the notion of willingness to communicate, the present study suggests that these two strands are ...

Bacteriology and Clinic: Ways to Reduce Misleading Answers)

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